Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. Its not about the science. 90,000 people don't have to die in the next 3 weeks. I have all of these on hand and I load up on vitamin D3 every day. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. The 5 observational studies is icing on the cake. more time. They never make things worse so are safe to try. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. 9th International Congress on Psychopharmacology 5th International Symposium on Child and Adolescent Psychopharmacology Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. This site requires JavaScript to run correctly. Hes a genuinely good guy. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. Design thinking was supposed to fix the world. Where did it go wrong. Has it really been 25 years, a whole quarter of a century? Doing something is better than nothing. Dosage there is 30mg once a day. The paramedics will think you are on drugs. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. The sooner you start, the better the outcomes. No long haul symptoms if you start the drug ASAP after first symptoms. Things took a final and dramatic turn once Kirsch started claiming the government was covering up vaccine deaths. Some countries dont have fluvoxamine so this is the alternative. Most doctors wont use it until NIH greenlights it, no matter what the science says. Once the Phase 2 result came out, it should have been embraced by doctors. Fluvoxamine is also an The incident, he added, was completely in keeping with his personality.. See this Wall Street Journal op-ed. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. One of the drugs, Fluvoxamine, showed a 30 . I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. What happens when your prescription drug becomes the center of covid misinformation. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. Its motivated out of his sense of keeping people safe and advancing health care.. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Always be self aware when using fluvoxamine. Di scl ai mer: T he vi ews expressed i n t hi s art i cl e are my own personal opi ni on based on my 1, 000+ hour st udy of cut t i ng edge . The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. No more. Why not fluvoxamine? For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine Their willingness to lie did. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. 19 In addition, several . Worst case, if we ignore all additional evidence so the average is a 60% pass rate. That is when the phase 2 results were published. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. Is that really true? Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. That study was featured on 60 Minutes. Steve put in $1MM of his own money and . People who report not tolerating the drug are typically prescribed too high a dose. Dr. Eric Lenze: So the results were really pretty. But the best way to help people is through rigorous trials that show what drugs help which people, and at what doses and timesnot by basing entire protocols on incredibly limited evidence. Lack of action. You cannot get any better than that. This is what the Seftel trial at Golden Gate fields used. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. The infectious disease scientists lied to me. Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. If you start later, doctors use higher dosages and compliance becomes a bigger problem. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. It will be months before enrollments are complete. Reason is the hospital gets release from liability if they follow NIH guidelines. All the supporting observational studies were positive as well. I see it all the time on social media, Morris told me. The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. Theyre finding alternative leaders to follow, Morris said. Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. I fully expected both organizations to do absolutely nothing. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. It does not matter how many lives will be saved. With cases spiking, the Los Angeles area banned gatherings. Some speaker, off camera, went on a . How can we get fluvoxamine? Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Hes spending his own money to do what he thinks is right. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. For decades, coders wrote critical systems in C and C++. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. Three of the four outpatient trials have been reported out: all were successful. The next major effect is that that fluvoxamine activates the sigma-1 receptor. . The CDC has advised everyone to wear a mask. That way you can start immediately. Some people report mild nausea while on the drug (stops when stop the drug). I believe they made the right decision and we should be rushing to follow their advice. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. The medical community doesnt care about saving lives. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. The NIH wrote a bullshit rejection because the FDA told them not to approve it. So why would we wait when lives are being lost? There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Zero. Ive used it personally at 50mg twice a day and experience no adverse events at all. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. The anecdotal data of 100% success rates is further icing on the cake. Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. Elsewhere he has said he began questioning vaccine safety after an unnamed Twitter follower told him several family members died after getting their shots. The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. . I took it myself at that dosage and noticed zero side effects. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. The combined p value of the two studies is <.0001. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. It has shown to be 100% protective of hospitalization in 2 clinical trials. They rejected the drug for insufficient evidence just like they always do for ivermectin. A video presentation by Steve Kirsch, Executive Director of the Covid-19 Early Treatment Fund. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. Im just telling you the truth. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. Don't underestimate the virus. I think we did rigorous reviews of proposals for research.. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). Another is to identify an asteroid that is going to hit the planet.. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Comparison with molnupiravir. We should not wait for the Phase 3 RCT. . Fluvoxamine (Luvox) is a Selective Serotonin Receptor Inhibitor (SSRI) that is clinically indicated for OCD in children, and can be used off label for depression. Still, in the moment, his question threw me, and I stuttered. Vaccine waitlist Dr. B collected data from millions. Its whether Merck can make a killing that matters. People who report not tolerating the drug are typically prescribed too high a dose. While Fauci was crafting national pandemic policies, Fauci's wife [Christine Grady, Chief Bioethicist, NIH] was back stopping [them]." Report coming soon. All can merit a fluvoxamine prescription based on traditional diagnoses. This drug can save your life but you have to ask for it! Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. Peter Meinke, another former board member, spent nearly three decades in drug discovery at Merck. Every year, we pick the 10 technologies that matter the most right now. Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. Download Citation | On Mar 1, 2023, Gne Seda Albayrak and others published A Cross-Sectional Study on the Personality Traits of Episodic and Chronic Migraine Patients | Find, read and cite all . We asked Steve to tone it down. You can help by bringing this document to your doctor's attention. Added to FLCCC protocols and Fareed-Tyson protocol among others. He has made millions from these projects, even if they have not turned him into a household name. Note that some of these articles are inaccurate. Here are my answers. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. This looks ominous, but it harmless. He's discovered a common medication that's highly effective in minimizing the impacts of COVID-19 - two studies have proven so. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Telling the truth, he tweeted. Some countries dont have fluvoxamine so this is the alternative. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. I couldnt tell I was on the drug. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Can I see your risk-benefit analysis?. There were no studies reported out so far where fluvoxamine made things worse or neutral. So there were too few events in the placebo group and they werent recruiting fast enough. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). just like ivermectin). After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. The web value rate of skirsch.io is 2 . There is an executive summary below, but the most important thing is that top infectious disease docs who have looked at all the evidence (including the two clinical trial results) believe the effect size is 75% or more in reducing the hospitalization rate. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. It does not matter how many lives will be saved. All can merit a fluvoxamine prescription based on traditional diagnoses. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients.