The priority list of what will drop from champion enemies in order is as follows: Soul Hearts - When you have no red heart containers and less than 2 soul hearts, Red Hearts (Full hearts) - While at 0.5 red hearts, Red Hearts (Full hearts) - When you have at least half a red heart container empty, Trinkets - If you have no trinkets and there are no trinkets on the ground in the room, Soul Hearts - When you have less than 6 total heart containers of any kind, If none of the above conditions are true, champions will resume dropping their regular pickups, UNLOCK: Unlock this item by defeating Greedier mode with Maggy, Allows you to fire tears diagonally by holding down two of the fire buttons at once, If you are using a gamepad, this item allows you to fire in any direction, The first enemy you kill in each new room will now explode and poison all nearby enemies, causing them to take periodic damage until they also die and explode, If you have lots of enemies near each other this can cause a chain reaction, killing lots of enemies in one go, Gives Isaac a finger which floats infront of him and points in the same direction he is facing or firing. When used, it retrieves the Forgotten skull, causing it to shoot back into your arms, Tainted Bethany - Spawns four random item wisps of high quality with significantly higher HP than normal, Tainted Jacob - Dark Esau splits into 2. It's possible to hold more than one trinket by taking Mom's Purse, Belly Button or using the Smelter to convert them into passive items. paper, roll, white, All of Isaac's bombs now having a homing effect when placed on the floor, * boss rush pool, boss rush room, item room, treasure room, item room pool, bomb beggar, dead, Tears can still hit Isaac if gravity applies for too long, Allows Isaac to squeeze between some objects, This item has a chance to spawn an additional curse room on each future floor, Causes a penny to spawn in all future Curse Rooms, Tears fired from your left eye gain roughly +28% fire rate increase, Causes your tears to be fired at staggered rates, Allows Angel Rooms to appears even if a Devil deal has been taken before, All shops now contain a trapdoor with a ladder, which leads down to a special shop. The main purpose of the Cracked Key is to unlock Tainted character in the Home floor without needing to find the Red Key. Below Polydactyly (454) and above Jacob's Ladder (494) vertically. grey, gray, green, mouth, bobs rotten head, bob rotten head, Teleports Isaac to a random location on the map, Can't be used to teleport to the I AM ERROR room, REPENTANCE - Teleport! This can make it confusing while navigating the room, Dataminer will randomly increase or decrease one of your stats by a small amount when used, Gives you the Fruit Cake effect for the room when used, which will give a random tear effect with every tear fired, All visual and tear effects reset after leaving the room, * data miner, red, pickaxe, minecraft, pixel, When used, this item will randomly change you into another character and remove the last item you picked up, All stat changes of the new character are applied (e.g. Now grants a half black heart upon use instead of a full soul heart. If you haven't unlocked Holy Mantle for The Lost yet, you won't gain the effect after touching a white fire so be careful! ?, Satan and The Lamb as Tainted Lazarus, All new chests become locked Golden chests, UNLOCK: Unlock this trinket by defeating Isaac, ?? spikes, creep). ?, Keeper and The Forgotten, UNLOCK: Unlock this item by defeating The Beast as Samson, The first time you take damage in a room, Isaac will become a ghost and time will stop for 3 seconds, During this ghost effect, you gain flight, spectral tears and the damage from the next hit you take is negated, Isaac returns to his body if you either clear the room or take damage while in ghost form, Only happens once per room - taking damage a second time does not turn you into a ghost again, UNLOCK: Unlock this item by defeating The Beast as Lazarus, Your tears are replaced with a charge attack that fires a homing, spectral fetus, The fetus tears deal damage equal to 75% of your current tear damage while in contact with enemies, roughly 5 times per second, Can't be held down like normal charge attacks, they will release automatically at full charge, UNLOCK: Unlock this item by defeating The Beast as Lilith, Gives you a familiar that can be charged up to release a black ring, that damages any enemies that touch it with rapid hits (similar to Maw of the Void / Athame effects), The effect does a decent amount of damage, but doesn't scale with your damage upgrades, UNLOCK: Unlock this item by defeating The Beast as Azazel, While firing tears, you now charge up a poop attack for 3 seconds that when released, fires from Isaac's behind, The poop attack deals your current tear damage to any enemies caught in the blast. Touching the white flame temporarily turns you into The Lost, but allows you to walk through the mirror into a mirrored version of this floor. rocks, poop) in the room and deal 200 damage to all enemies in the current room, as well as every other room for the remainder of the floor, Also opens the boss rush door after Mom's Foot, blue womb door after Mom's Heart, secret rooms and super secret rooms, Like all single-use items, this item cannot be absorbed and used multiple times by the Void item, Entering a room with an angel statue will destroy it and automatically spawn one of the Angel mini bosses, REPENTANCE - This now blows up machines, beggars and fireplaces too, Upon use, this item will fart, pushing enemies away and causing a wave of rocks to spawn that spread outwards from Isaac in a circle, dealing 10 damage per hit to any enemies caught in it, Visually this item is very similar to Butter Bean, The rock waves can destroy destructible objects, e.g. Hover over any item to see detailed and accurate descriptions taken directly from the game's source code. Items that are better than the average and are good additions to have on most builds. chalice, indiana jones, * angel room pool, god room pool, angel room item, bird, white, Every time you use this item it deals 40 damage to all enemies in the room and Isaac also takes damage, The first use per room takes 1 full heart, then 0.5 hearts per use after that, Shields and invincibility effects do not prevent damage when using this item, Using with Isaac's Heart previously prevented you from taking damage, however in Repentance this was fixed, Using this item as The Lost will instantly kill him, even if you have Holy Mantle active, UNLOCK: Unlock this item by beating Satan with Samson, * item room, treasure room, item room pool, razor, straight, edge, barber, bloody, brown, silver, Follows behind Isaac and can be swung back and forth, dealing 5 contact damage per tick to anything it hits, Every time the hairball kills an enemy, it grows in size allowing it to deal more damage, This is one of the items which allows you to transform into Guppy, Moving to a new floor decreases the size of the hairball, * devil pool, devil room pool, devil deal, grey, brown, pile, guppys hairball, guppy hairball, A familiar that mirrors the player's movements and shoots tears directly at Isaac, Abel's tears do 3.5 damage, unless playing as Cain in which case they do 5, REPENTANCE - Abel now has an increased rate of fire, and will mirror to the other side of the room, even if it's off screen. Based on the Steam Workshop mod created by Scayze and Ashkait, *, eyes, eyeball, bloody, white, red, googly googley, bank shot, Upon entering a room, a skull appears over a random enemy's head, Killing the marked enemy will cause the skull to move to a different enemy, If all enemies in the room are cleared in the order they are marked, Isaac gains a random reward from one of the following: Soul heart, Key, Pill, Bomb, Nickel, +0.2 Speed, +0.5 Range, +0.5 Tears, +1 Flat damage or +1 luck, Killing enemies in the wrong order will end the streak and deny you any extra rewards, Added as part of the Afterbirth+ Booster Pack #4. This means the trinket does nothing if your active item isn't fully charged, Single-use active items are consumed as normal, Doors can be opened without using up a key, However, when entering the door you are taken to a blue womb room with enemies to defeat. Possible tear effects: Fire Mind, Spoon Bender, My Reflection, Ouija Board, 20/20, Inner Eye, Iron Bar, Death's Touch, Scorpio, Tough Love . REPENTANCE - +0.2 Speed Up (Used to be -0.1 Speed before Repentance). The special shop contains various consumables and items at a higher price from the Devil/Angel room, Boss room and Secret room pools. ?, Satan and The Lamb as Tainted Lilith, All shops only sell familiars while holding this trinket, If you enter a shop while holding this trinket, the effect won't undo by dropping it until you move to a new floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Lilith, Every time an enemy dies you have a chance to gain a random Locust, Different color Locusts correspond to the horsemen. One of the following messages may show: "Some doors require a blessing. It grows rapidly in size then explodes into a gas cloud that damages nearby enemies, When the explosion happens, more homing fungus tears fire out in random directions. Each time you clear a room there is a chance a Red Room will spawn at one of the walls. yellow, white, triangle, The three heart containers are pre-filled with red hearts, UNLOCK: Unlock this item by beating the Chest with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, real platinum god, the lost item pool, Enemy projectiles will now slowly curve away from Isaac and avoid hitting him, UNLOCK: Unlock this item by beating Dark Room with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, It will attempt to hide behind you when shooting. Spindown Dice itself will be rerolled into Anima Sola, while Hypercoagulation rerolls into it. Killing a petrified enemy will freeze it. Recharge time: Starts at 1 second, increasing by every time you use it. It rerolls enemies and pickups it comes into contact with, then despawns. If you didn't find one before this point, there will be a tinted Skull somewhere on Depths II, which contains a Fool card when blown up. The creep deals 2 damage per tick while enemies stand in it, Lazarus' revived form (Lazarus II) respawns with this item, * item room, treasure room, item room pool, blood drop, red blood, drip, Gives Isaac a guaranteed devil or angel room on every floor that they can appear, even if you have already beaten the boss and it didn't show up originally, Taking the Goat Head (or any other item) in a Devil Deal bars you from encountering Angel Rooms naturally. You get a couple of seconds of invincibility to move away after, The main benefit of this Soul Stone is that it automatically activates if you die, meaning it is effectively an extra passive life while held, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lazarus, Activates the D6 and D20 effects, rerolling all items and pickups in the room. UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons), When used, will open all doors in the current room, similar to a one-time use of Dad's Key, UNLOCK: Unlock this card by beating Challenge #22 (Speed), When used this card will activate a use of your spacebar item for free, When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances, UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black), When used this rune will double all pickups on the floor in the room, Creates copies of pickups in the Shop which can be taken for free, even if you haven't purchased them yet, Can be used to double the number of item chests in the first room of the final Chest / Dark Room floors, Cloned chests have the same types of items as the first one, Cannot be used to clone trinkets or other Jera runes, UNLOCK: Unlock this card by beating Challenge #2 (High Brow), UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma), Removes the curse which is in effect on the current floor (except Curse of the Labyrinth), Can also cure the effect of the Amnesia pill, UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls), When used, reveals the entire map including all the secret room locations and other icon rooms, UNLOCK: Unlock this card by beating Challenge #5 (The Tank), Rerolls all pedestal items in the current room (One time use of the D6), UNLOCK: Unlock this card by beating Challenge #6 (Solar System), Summons 3 blue friendly spiders and 3 blue flies, UNLOCK: Unlock this card by beating Challenge #20 (Purist), When used, gives you an invincibility effect which lasts for 20 seconds, UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue), When used, gives a random Mystic rune effect, Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro, Also has a 25% chance to spawn another Blank Rune upon use, UNLOCK: Unlock this card by beating Challenge #30 (Guardian), When used, this rune deals 40 damage to all enemies in the room and consumes all pedestal items in the room, giving you a random stat increase for each item consumed, Also consumes all pickups in the room and turns them into blue flies and spiders, UNLOCK: Unlock this item by beating Greedier mode as Apollyon. Collection Page (Repentance) - Binding of Isaac: Rebirth Wiki Based on the Steam Workshop mod (originally called Water Balloon) created by HiHowAreYou, UNLOCK: Unlock this item by picking up the Blood Clot item 10 times, Isaac's tears slow down over time while moving across the room, and upon stopping completely or hitting an object will burst into 8 smaller tears which fire in all directions, This item will also allow you to 'feed' a tear with other tears. REPENTANCE - The Nail's temporary damage bonus has been increased, and is now able to stack with itself. The spear occasionally inflicts fear on enemies it damages.